Einladung zum Vortrag im Kolloquium Technische Kybernetik

Dynamics of metabolic ¹³C labeling networks

Prof. Dr.rer.nat.habil. Wolfgang Wiechert

    Zeit: Dienstag · 7. 1. 2002 · 16:00 Uhr
    Ort: Hörsaal V 9. 31 · Pfaffenwaldring 9 · Campus Stuttgart-Vaihingen

Abstract

The detailed quantitative knowledge of the metabolic fluxes in a living cell are of great importance for the development of biotechnological production processes. ¹³C metabolic flux analysis (MFA) - after several years of development - now is a well established tool to determine these fluxes. ¹³C MFA is based on experiments with ¹³C labeled substrates. The ¹³C label is distributed over the intracellular metabolite pools by the metabolic activity until finally, it can be measured by NMR or MS instruments.
The mathematical core of this method is a high dimensional model for the dynamics of ¹³C labeling in the intracellular metabolite pools. The mathematical structure of metabolic ¹³C labeling systems is now fully understood and in particular the global stability of these systems can be proven. From this proof several conclusions for the numerical computation of the stationary and transient states can be drawn. The transients has become of great interest for flux analysis under instationary metabolic conditions.

Biografische Information

1985	Abschluß als Diplom-Mathematiker mit Nebenfach Informatik.
1986-90	Mitarbeiter am Institut für Biotechnologie 2 des Forschungszentrums Jülich und am Institut für Mikrobiologie und Biotechnologie der Universität Bonn.
1990	Promotion im Fachbereich Theoretische Biologie (Schwerpunkt: Modellierung biologischer Systeme)
1990-96	Wissenschaftlicher Angestellter am Institut für Biotechnologie 2 des Forschungszentrums Jülich.
1996	Habilitation im Fachbereich Theoretische Biologie (Metabolic Engineering) an der Universität Bonn.
seit 1996	Professor für Simulationstechnik an der Universität-GH Siegen.