Einladung zum Vortrag im Kolloquium Technische Kybernetik

Systems Biology of Halophilic Archaea

Prof. Dieter Oesterhelt
Department of Membrane Biochemistry
Max Planck Institute of Biochemistry
Martinsried

    Zeit: Dienstag · 15. 5. 2007 · 14:30 Uhr
    Ort: IST-Seminarraum 3.241 · Pfaffenwaldring 9 · Campus Stuttgart-Vaihingen

Abstract

Archaea, the third kingdom of life, offer some attractive modules for a systems biology approach. Based on an extensive genomic transcriptomic and proteomic analysis of this organism we selected genom wide modelling of metabolism, analysis of changes in life style on the basis of quantitative proteomics and signal transduction as focal areas for application of the iterative cycle of modelling and experimentation.

The best examples so far are metabolism and phototaxis in which the input of photons of different quality and intensity is integrated via a two-component system and results is an output at the flagellar motor of the cell as a modulated response time for a stop. The archaeal flagellar motor although not known for its molecular components which couldn't even be unrevealed by genomic analysis nevertheless can be very exactly described in its unstimulated and stimulated behaviour. Coupled as a module to two photoreceptors mediating three light responses of the cell a first quantitative model of signal transduction could be established, which covers all aspects of phototaxis in these archaeal cells and explains the experimental results of the past 20 years. The model further unifies and includes also very different models proposed over the years from various labs, none of which cover all experimental results. An introduction into the system and a detailed description of the model of the signal transduction cascade will be presented.

Biographical Information

Geboren am 10. November 1940 in München. Studium der Chemie an der Univ. München, Promotion (1967) und Habilitation (1973) Univ. München, Leiter einer biologischen Arbeitsgruppe am Friedrich-Miescher-Laboratorium der Max-Planck-Gesellschaft in Tübingen (1973-1975), o. Professor am Institut für Biochemie der Univ. Würzburg (1975-1979), Direktor und Wissenschaftliches Mitglied am Max-Planck-Institut für Biochemie (seit 1979).