Einladung zum Vortrag im Kolloquium Technische Kybernetik

Robustness and sensitivity analysis of biochemical networks

Prof. Elling Jacobsen
School of Electrical Engineering
Royal Institute of Technology
Stockholm
Sweden

    Zeit: Dienstag· 29. 01. 2008 · 16:00 Uhr
    Ort: IST-Seminarraum 3.241 · Pfaffenwaldring 9 · Campus Stuttgart-Vaihingen

Abstract

Robustness and sensitivity of cellular functions is a key topic in biology, and one in which systems biology can make a profound contribution to our understanding of living systems. In this talk I will discuss various approaches to robustness and sensitivity analysis of biochemical network models. The focus will be on an approach, based on concepts from robust control theory, in which we consider general type dynamic perturbations applied to the edges of the network. The proposed method does not merely provide quantitative measures of sensitivity and robustness, but can also identify specific network fragilities and elucidate the mechanisms critical to robustness and sensitivity of a given function. Through the talk I will use several examples, including circadian clocks and bistable genetic switches, for illustration.

Biographical Information

Elling W. Jacobsen received the PhD degree in Chemical Engineering from the Norwegian University of Science and Technology in 1991. After postdoctoral positions at Caltech and Imperial College, he joined the Department of Automatic Control at KTH in Stockholm, where he is currently a full professor. His main research interests are in modeling and analysis of chemical and biochemical process systems, with a particular focus on the impact of system structures on dynamic properties.