Einladung zum Vortrag im Kolloquium
Technische Kybernetik
Modeling and Analysis of Protein Synthesis Processes in Eukaryotic Cells
Prof. Nadav Skjøndal-Bar
Department of Chemical Engineering
Norwegian University of
Science and Technology
Trondheim
Norway
Zeit: Montag 16. 06.
2008
· 15:00 Uhr
Ort: IST-Seminarraum 3.241 · Pfaffenwaldring
9 · Campus Stuttgart-Vaihingen
Abstract
It was found in the last decade that gene
regulation in the level of translation is mainly effected by the
initiation process. Eukaryotic initiation factors (eIF-) 2 and 4
are the main components that regulate gene expression by enabling the
40S ribosomal subunit structure to bind to a pre-initiation complex
eIF-4F. The process is complex and involves many different regulating
components. This research proposed dynamic models for the eIF-2 and -4
regulation processes. A further simplification of the eIF-2 process was
presented and nonlinear analysis proved L2 stability of the process.
Simulations and analysis of the reduced model led to several
conclusions about the affect of a few principle factors in the eIF-2
initiation process (namely eIF-2B, phosphorylated and
non-phosphorylated eIF-2 and GCN2), consistent with recent experiments
in yeasts. A nonlinear feedback control loop was proposed, which can
drive the production of protein to a desired set-point using the
controllable states.
Biographical Information
Dr. Nadav Skjøndal Bar is an associate professor of Systems Biology at
the Department of Chemical Engineering, Norwegian University of Science
and Technology, Norway.
In his Master Thesis, he developed a novel algorithm to apply a rapid
MPC using an offline nonlinear optimization problem and an efficient
online Newton-Rapson. Later, a dynamic predictive model was
developed in his Phd, which predicts nutrient pathways in fish. The
model was commercialized to a software which predicts growth, body
composition in fish in order to optimize feed. Dr. Bar also has several
publications on translational control of gene expression. He is
currently working on protein modeling transcription and translational
control in prokaryotics and eukaryotics.
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