Einladung zum Vortrag im Kolloquium
Technische Kybernetik
Bridging Network Topology and Dynamics: The Coupled Feedback Loops in
Complex Signaling Networks
Prof. Kwang-Hyun Cho
Department of Bio and Brain Engineering & KI for the
BioCentury
Korea Advanced Institute of Science and Technology (KAIST)
Yuseong-gu, Daejeon
Republic of Korea
Zeit: Montag 30. 06.
2008
· 16:00 Uhr
Ort: V 7.22 · Pfaffenwaldring
7 · Campus Stuttgart-Vaihingen
Abstract
Life sciences witness a shift of paradigm
from traditional characterization of individual molecules towards an
understanding of interactive pathways and networks. I believe that the
role of genes, proteins, metabolites and cells can be understood and
defined through their interactions and it is this very focus on intra-
and inter-cellular dynamics that I am deeply involved in the emerging
area of Systems Biology with a particular focus on signaling networks.
Different signal transduction pathways often share information through
cross-talks. Such cross-talks can form feedback loops that play
important roles in the regulation of cell growth, proliferation, and
differentiation in response to external stimuli. Intriguingly, those
feedback loops are frequently found as a coupled structure in complex
cellular circuits. We have investigated the coupled feedback loops in
various cellular circuits and determined the dynamical role of each
coupled structure. In particular, we have found that the coupled
positive feedbacks enhance signal amplification and bistable
characteristics; the coupled negative feedbacks promote homeostasis;
and the positive and negative feedbacks together enable a reliable
decision making process by properly modulating signal responses and
noises. We have further investigated the role of those coupled feedback
loops in large-scale networks and evaluated their critical implications
in robustness, fragility, and essentiality. In this presentation, I
will describe that studying the complex dynamics of multiple feedback
loops is a key to understanding the regulatory mechanisms in signal
transduction pathways.
Biographical Information
Professor Kwang-Hyun Cho received the B.S., M.S., and Ph.D. degrees in
electrical engineering from the Korea Advanced Institute of Science and
Technology (KAIST) in 1993, 1995, and 1998, respectively. He worked at
the University of Ulsan in Korea, the University of Manchester
Institute of Science and Technology (UMIST) in the U.K., the Royal
Institute of Technology in Sweden, the Hamilton Institute in Ireland,
the Seoul National University in Korea (at the Medical School), and he
is currently an invited tenured Associate Professor in the Department
of Bio and Brain Engineering at the Korea Advanced Institute of Science
and Technology (KAIST) and a director of Laboratory for Systems Biology
and Bio-Inspired Engineering (http://sbie.kaist.ac.kr). He has been
guest editors of numerous journals for the special issue of systems
biology and has given a number of plenary/keynote talks at
international conferences on systems biology. He co-founded Systems
Biology as an Editor-in-Chief which is the world-first international
journal in systems biology launched by IEE (changed to IET in 2007) in
London from 2004. He is also an Editorial Board Member of Systems and
Synthetic Biology (Springer), BMC Systems Biology, Gene Regulation and
Systems Biology (Libertas), and Molecular BioSystems (RSC). He is a
Senior Member of the IEEE Engineering in Medicine and Biology Society
(EMBS). His research interests cover the areas of systems science with
bio-medical applications including systems biology and bio-inspired
engineering based on molecular systems biology. He published 86
international journal papers and contributed to 7 books/book chapters
in these areas.
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