Einladung zum Vortrag im Kolloquium
Remarks on Interconnections, Modularity, and Dynamics in Systems Biology
Prof. Eduardo Sontag
Department of Mathematics
Piscataway, New Jersey, USA
Zeit: FREITAG 20.02.2009
· 14:00 Uhr
Ort: IST Seminarraum 3.241 · Pfaffenwaldring 9 ·
For systems made up of interconnected components, it would be desirable to be
able to deduce global behaviors through a bottom-up analysis, based on partial
knowledge of the input/output behaviors of the individual components. This is
particularly important in the field of systems biology, where neither internal
descriptions nor complete input/output behaviors are usually available. From
a systems and control theory perspective, many new theoretical problems and
exciting directions for research arise.
Two sources of difficulty in any modular approach are (a) impedance or
"dynamic retroactivity" effects due to resource sharing, (b) feedback loops
that expose modes of behavior that were "hidden" when individual subsystems
had been studied in isolation, and (c) the lack of sufficient input variation.
This talk, which is based on research done in collaboration with David Angeli,
Murat Arcak, Domitilla Del Vecchio, and others, discusses mathematical
concepts and theoretical results that address some of these issues, including
the use of monotone systems theory or passive systems theory to deal with the
"hidden behavior" problem and the lack of richness in input classes, and the
introduction of a modeling framework to represent dynamic retroactivity
Eduardo Sontag received his undergraduate degree in Mathematics from the
University of Buenos Aires in 1972, and his Ph.D. in Mathematics from the
University of Florida in 1976. His Ph.D. advisor was Rudolf E. Kalman.
Sontag's major research interests include areas of systems molecular biology,
control theory, bioinformatics, and learning and neural networks.
Since 1977, Sontag has been with the Department of Mathematics at Rutgers
University, where he is a Professor of Mathematics as well as a Member of the
Graduate Faculties of the Department of Computer Science and of the Department
of Electrical and Computer Engineering. He is also the director of SYCON, the
Rutgers Center for Systems and Control, and is a co-founder and a member of
the Advisory Committee of the BioMaPS Institute for Quantitative Biology. He
is in the Editorial Board of IET Systems Biology, SIAM Review, Synthetic and
Systems Biology, International Journal of Biological Sciences, Nonlinear
Analysis: Hybrid Systems, Nonlinear Dynamics and Systems Theory, and the
Journal of Computer and Systems Sciences, and is a co-founder and co-Managing
Editor of Mathematics of Control, Signals, and Systems.
Sontag is an IEEE Fellow, and was awarded the Reid Prize (SIAM) in 2001, the
Bode Prize (IEEE) in 2002, and the 2002 Board of Trustees Award for Excellence
in Research and the 2005 Teacher/Scholar Award from Rutgers.