Einladung zum Vortrag im Kolloquium Technische Kybernetik

  Model reduction for combinatorial signaling systems

Prof. Dr. techn. Heinz Koeppl
Professor for System Theory in Biology
Automatic Control Laboratory, ETH Zurich
Switzerland

Tuesday, 30. November 2010, 4:00 p.m.
IST-Seminar-Room 3.243 • Pfaffenwaldring 9 • Campus Stuttgart-Vaihingen

Abstract

Induction of signaling cascades gives rise to transient complex formation and mutual modification of proteins that in turn often results in a combinatorial number of non-isomorphic reachable protein complexes. The classical species-based dynamics of chemical kinetics is rather unsuitable to describe such assembly processes. Exploiting the local context on which many bio-molecular events are conditioned, one can obtain a state space of reduced dimension with respect to the species-based dynamics. In this talk I will discuss different such coarse graining techniques and outline an exact reduction of the underlying Markov jump process starting from a rule-based specification.

Biographical Information

Heinz Koeppl studied physics at Graz Karl-Franzens University in Austria (M.Sc.) and completed his Ph.D. in fall 2004 at the department of electrical engineering and information technology of Graz University of Technology. Since then his has been a postdoc at UC Berkeley and EPF Lausanne. With fall 2010 he is an professor for System Theory in Biology at the Automatic Control Lab of ETH Zurich. His focus is on calibration and reduction of mechanistic models for cellular signal transduction systems.