Dipl.-Biol. (t.o.)

Dirke Imig

Research Assistant
Institute for Systems Theory and Automatic Control

Contact

+49 711 685-67749
+49 711 685-67735

Business card (VCF)

Pfaffenwaldring 9
70569 Stuttgart
Germany
Room: 3.241

Subject

My research interests are in the field of Systems Biology , especially modeling and analysis of heterogeneous cell populations, individual-based modeling, modeling and analysis of TRAIL-induced apoptotic response of cancer cell populations.

Conferences
[1] D. Imig, K. Kuritz, N.Pollak, M. Rehm, F. Allgöwer.
Death patterns resulting from cell cycle-independent cell death.
Poster Präsentation, Foundation of Systems Biology in Engineering (FOSBE) in Chicago (Illinois, USA), 2018.
[2] D. Imig, N. Pollak, F. Allgöwer.
Cell populations during apoptotic treatment.
Poster Präsentation, SBHD in Heidelberg, 2017.
[3] D. Imig, N. Pollak, S. Waldherr, F. Allgöwer.
Analysis of cell population dynamics during apoptotic treatment via mathematical modeling.
Poster presentation, Design, optimization and control in systems biology and synthetic biology in Paris, 2015.
[4] D. Imig, F. Richter, W. Halter, N. Pollak, F. Allgöwer, S. Waldherr.
Cell population dynamics during apoptotic stimulation via mathematical modeling.
Poster presentation, Foundations of Systems Biology in Engineering (FOSBE) 2015 in Boston (USA), 2015.
[5] D. Imig, N. Pollak, C. Meyer, D. Stöhr, F. Richter, S. Waldherr, F. Allgöwer.
TRAIL treatment in cancer cell populations: Individual-based modeling and experiments.
Poster presentation, EMBL Symposium: Cellular Heterogeneity 2015 in Heidelberg (Germany), 2015.
[6] D. Imig, S. Waldherr, T. Strecker, S. Neumann, N. Pollak, P. Scheurich, F. Allgöwer.
Simulations and predictions of TRAIL response in lung cancer cell populations via mathematical modeling.
Poster presentation, 5th Conference on Systems Biology of Mammalian Cells (SBMC) in Berlin (Germany), 2014.
[7] D. Imig, N. Pollak, T. Strecker, P. Scheurich, F. Allgöwer, S. Waldherr.
Simulations and predictions of the response of heterogeneous cancer cell populations to apoptosis induction.
Poster presentation, Computational Models in Biology and Medicine in Cologne (Germany), 2014.

Journal Articles
[1] D. Imig, N. Pollak, T. Strecker, P. Scheurich, F. Allgöwer, and S. Waldherr.
An individual-based simulation framework for dynamic, heterogeneous cell populations during extrinsic stimulations.
Journal of Coupled Systems and Multiscale Dynamics, 2015.
[2] L. Danish, D. Imig, F. Allgöwer, P. Scheurich, and N. Pollak.
Bcl-2-mediated control of TRAIL-induced apoptotic response in the non-small lung cancer cell line NCI-H460 is effective at late caspase processing steps.
Plos One, 2018.
[3] F. A. Lincoln, D. Imig, C. Boccellato, V. Juric, J. Noonan, R. E. Kontermann, F. Allgöwer, B. M. Murphy, M. Rehm.
Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism.
Cell Death and Disease, 2018.


Thesis
[1] Development of a rule-based model of the assembly of the TOM complex in Saccharomyces cerevisiae.
Diploma Thesis, Institute for System Dynamics, University of Stuttgart (Germany), 2012.

Talks
[1] Mathematical modeling and simulations of TRAIL response in heterogeneous cell populations.
Workshop of the Institute of Cell Biology and Immunology, Freudenstadt (Germany), March 2014.
[2] Mathematical modeling and analysis of ligand-induced apoptosis in cancer cell populations.
Milestone Presentation, Graduate School Simulation Technology, University of Stuttgart (Germany), November 2014.
[3] Individual-based modeling of apoptosis in cancer cell populations.
Workshop 1 - 2015, Stuttgart Research Center Systems Biology (SRCSB), Stuttgart (Germany), February 2015.
 

  • Assistance for exercises and exam in Systemdynamische Grundlagen der Regelungstechnik (SoSe 17, SoSe 18)
  • Assistance for exam in Einführung in die Regelungstechnik (SoSe 13, WS 13/14, SoSe 14, WS 14/15)
  • Assistance in Praktikum Systembiologie - Vom Experiment zur Simulation (WS 14/15, WS 15/16)
  • Organizing of Praktikum Konzepte der Regelungstechnik (WS 12/13, WS 13/14, WS 14/15, WS 15/16)
  • Organizing of Praktikum Einführung in die Regelungstechnik (SoSe 13, SoSe 14, SoSe 15, SoSe 16, SoSe 17, SoSe 18)
  • Organizing of Angewandte Regelung und Optimierung in der Prozessindustrie (SoSe 13, WS 13/14)
  • General contact person for (WS 12/13, SoSe 13, WS 13/14)
  • Supervision of student theses
  • PhD speaker of Graduate School Simulation Technology (2013)


since 09/2012 Research assistant at the Institute for Systems Theory and Automatic Control
07/2012 Diploma in Technical Biology
2006-2012 Studies in Technical Biology at the University of Stuttgart, Germany
  • Diploma thesis: "Development of a rule-based model of the assembly
    of the TOM complex in Saccharomyces cerevisiae"
    at the Institute for System Dynamics , University of Stuttgart
  • Student research project at CSIRO in Melbourne, Australia
since 2009 Scholar of the German National Academic Foundation
2006 Abitur at Herzog-Johann Gymnasium in Simmern, Germany
 
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